Cytoreductive surgery for advanced-stage ovarian cancer

Cytoreductive surgery for advanced ovarian cancer: quo vadis?

Two-thirds of women who are newly diagnosed with invasive epithelial ovarian cancer present with stage III or IV disease.The preferred initial treatment has traditionally consisted of primary surgical debulking followed by platinum-based chemotherapy. However, recent data suggesting comparable efficacy for neoadjuvant chemotherapy and interval debulking have challenged this conventional dogma. ...

Cytoreductive surgery in ovarian cancer

As the overall prognosis for patients with ovarian cancer is poor, the management of this condition should be restricted to expert multi-disciplinary teams in gynaecological oncology. Apparent early stage ovarian cancer requires accurate and complete staging so that potential sites for metastases are not missed. Omitting adequate staging may have significant consequences including a negative im...

3. Cytoreductive surgery for ovarian cancer

(1) Surgery for diagnostic purposes: This kind of surgery could be performed at any time in the course of ovarian cancer (e.g. to get a histological diagnosis). Second-look surgery belongs to this group of procedures. It is an operation performed in patients who are clinically free of disease after the completion of a defined course of chemotherapy with the purpose to confirm the response statu...

Optimum Surgery in Advanced-stage Ovarian Cancer

Primary cytoreductive surgery for advanced ovarian cancer: is it the past, present, or future?

Ovarian cancer accounts for more deaths in the United States than all other gynecologic malignancies combined. This is largely due to the fact that no effective screening test has been identified thus far to facilitate early detection. As a result, two-thirds of women continue to be diagnosed with advanced stage III or IV disease. Historically, the standard of care has consisted of primary cyto...